The Progression of Serum Prorenin Concentration during Pregnancy

The Renin Angiotensin System (RAS) also has an important role in hypertension: it maintains the constancy of Blood Pressure (BP) during pregnancy, which increases the cardiac output and circulating plasma volume [2]. Patients with PIH are sensitive to the pressor effects of Angiotensin 2 (AT2) compared to normotensive pregnant women [3,4], and Gant et al. reported that an AT2 infusion test may predict the onset of preeclampsia [2], suggesting that the RAS is associated with the pathogenesis of PIH. The (Pro) Renin Receptor [(P)RR], a new component of the RAS, was discovered by Nguyen ftable in 2002 [5]. Wanatabe et al. reported that pregnant women with Plasma-Soluble (P) Rr [s(P)RR] concentrations above the 75th percentile at delivery had a significantly increased risk of preeclampsia [6]. In addition, RAS may have an important role in fetal development [7,8], and tissue RAS may be crucial for placentation and the pathogenesis of PIH [9]. Since Prorenin (PR) combined with (P) RR activates the tissue RAS, we evaluated the serum PR concentration during pregnancy to determine whether PR is also associated with PIH. Materials and Methods